Poly ICLC is an immunostimulant. It is polyinosinic-polycytidylic acid (poly I:C) mixed with the stabilizers carboxymethylcellulose and polylysine. It is under trial for use in cancer.

Poly I:C is a ligand for toll like receptor-3, which usually triggers on the structurally similar double-stranded RNA present in some viruses.

References

External links

  • National Cancer Institute: poly ICLC



Example of radiographic response in a patient given poly ICLC. Left

PolyICLC administration significantly improves the therapeutic effects

The addition of PolyICLC and GMCSF can improve the detection of

PolyICLC induces IFN/ in mice. IFN was measured in BALB/c mice

PolyICLC administration enhances vaccineinduced specific CTL